Package: simIDM 0.1.0.9005
![](https://github.com/insightsengineering/simIDM/raw/HEAD/man/figures/logo.png)
simIDM: Simulating Oncology Trials using an Illness-Death Model
Based on the illness-death model a large number of clinical trials with oncology endpoints progression-free survival (PFS) and overall survival (OS) can be simulated, see Meller, Beyersmann and Rufibach (2019) <doi:10.1002/sim.8295>. The simulation set-up allows for random and event-driven censoring, an arbitrary number of treatment arms, staggered study entry and drop-out. Exponentially, Weibull and piecewise exponentially distributed survival times can be generated. The correlation between PFS and OS can be calculated.
Authors:
simIDM_0.1.0.9005.tar.gz
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simIDM.pdf |simIDM.html✨
simIDM/json (API)
NEWS
# Install 'simIDM' in R: |
install.packages('simIDM', repos = c('https://pharmaverse.r-universe.dev', 'https://cloud.r-project.org')) |
Bug tracker:https://github.com/insightsengineering/simidm/issues
multistate-modelssimulation-engine
Last updated 17 days agofrom:99455c6886. Checks:OK: 7. Indexed: no.
Target | Result | Date |
---|---|---|
Doc / Vignettes | OK | Aug 22 2024 |
R-4.5-win | OK | Aug 22 2024 |
R-4.5-linux | OK | Aug 22 2024 |
R-4.4-win | OK | Aug 22 2024 |
R-4.4-mac | OK | Aug 22 2024 |
R-4.3-win | OK | Aug 22 2024 |
R-4.3-mac | OK | Aug 22 2024 |
Exports:addStaggeredEntryassert_intervalsassert_positive_numberavgHRExpOSavgHRIntegExpOScensoringByNumberEventscorPFSOScorTransempSignificantestimateParamsExpHazOSexponential_transitionExpQuantOSExpSurvOSExpSurvPFSexpvalOSIntegexpvalPFSInteggetCensoredDatagetClinicalTrialsgetDatasetWideFormatgetEventsAllgetInitgetNumberEventsgetOneClinicalTrialgetOneToTwoRowsgetPCWDistrgetPWCHazardgetResultsgetSimulatedDatagetSumPCWgetTargetgetTimePointgetWaitTimeSumhazlog_p11logRankTestnegLogLikpassedLogRankPCWInversionMethodpiecewise_exponentialprepareDatapwAPWCsurvOSPWCsurvPFSsurvOSsurvPFSsurvPFSOSsurvTranstrackEventsPerTrialWeibSurvOSWeibSurvPFSweibull_transition
Dependencies:backportscheckmateclicodetoolsdata.tabledigestfurrrfutureglobalsgluelatticelifecyclelistenvmagrittrMatrixmstateparallellypurrrRColorBrewerrlangsurvivalvctrsviridisLite
Correlation between PFS and OS
Rendered fromcorrelation.Rmd
usingknitr::rmarkdown
on Aug 22 2024.Last update: 2023-12-11
Started: 2023-12-07
Getting Started
Rendered fromquickstart.Rmd
usingknitr::rmarkdown
on Aug 22 2024.Last update: 2023-12-11
Started: 2022-07-18
Piecewise Constant Hazards Calculations
Rendered frompwc_survival.Rmd
usingknitr::rmarkdown
on Aug 22 2024.Last update: 2023-12-11
Started: 2023-12-07
Power and Type I Error Calculations
Rendered fromtrialplanning.Rmd
usingknitr::rmarkdown
on Aug 22 2024.Last update: 2024-01-10
Started: 2023-01-18