---
title: "Using regression plots"
author: "NEST CoreDev"
output: rmarkdown::html_vignette
vignette: >
  %\VignetteIndexEntry{Using regression plots}
  %\VignetteEngine{knitr::rmarkdown}
  %\VignetteEncoding{UTF-8}
---


# `teal` application to use regression plot with various datasets types

This vignette will guide you through the four parts to create a `teal` application using
various types of datasets using the regression plot module `tm_a_regression()`:

1. Load libraries
2. Create data sets
3. Create an `app` variable
4. Run the app

## 1 - Load libraries

```{r library, echo=TRUE, message=FALSE, warning=FALSE, results="hide"}
library(teal.modules.general) # used to create the app
library(dplyr) # used to modify data sets
```

## 2 - Create data sets

Inside this app 4 datasets will be used

1. `ADSL` A wide data set with subject data
2. `ADRS` A long data set with response data for subjects at different time points of the study
3. `ADTTE` A long data set with time to event data
4. `ADLB` A long data set with lab measurements for each subject

```{r data, echo=TRUE, message=FALSE, warning=FALSE, results="hide"}
data <- teal_data()
data <- within(data, {
  ADSL <- teal.modules.general::rADSL %>%
    mutate(TRTDUR = round(as.numeric(TRTEDTM - TRTSDTM), 1))
  ADRS <- teal.modules.general::rADRS
  ADTTE <- teal.modules.general::rADTTE
  ADLB <- teal.modules.general::rADLB %>%
    mutate(CHGC = as.factor(case_when(
      CHG < 1 ~ "N",
      CHG > 1 ~ "P",
      TRUE ~ "-"
    )))
})
datanames <- c("ADSL", "ADRS", "ADTTE", "ADLB")
datanames(data) <- datanames
join_keys(data) <- default_cdisc_join_keys[datanames]
```

## 3 - Create an `app` variable

This is the most important section. We will use the `teal::init()` function to
create an app. The data will be handed over using `teal.data::teal_data()`. The app
itself will be constructed by multiple calls of `tm_a_regression()` using different
combinations of data sets.

```{r app, echo=TRUE, message=FALSE, warning=FALSE, results="hide"}
# configuration for the single wide dataset
mod1 <- tm_a_regression(
  label = "Single wide dataset",
  response = data_extract_spec(
    dataname = "ADSL",
    select = select_spec(
      label = "Select variable:",
      choices = variable_choices(data[["ADSL"]], c("BMRKR1", "BMRKR2")),
      selected = "BMRKR1",
      multiple = FALSE,
      fixed = FALSE
    )
  ),
  regressor = data_extract_spec(
    dataname = "ADSL",
    select = select_spec(
      label = "Select variables:",
      choices = variable_choices(data[["ADSL"]], c("AGE", "SEX", "RACE")),
      selected = "AGE",
      multiple = TRUE,
      fixed = FALSE
    )
  )
)

# configuration for the two wide datasets
mod2 <- tm_a_regression(
  label = "Two wide datasets",
  default_plot_type = 2,
  response = data_extract_spec(
    dataname = "ADSL",
    select = select_spec(
      label = "Select variable:",
      choices = variable_choices(data[["ADSL"]], c("BMRKR1", "BMRKR2")),
      selected = "BMRKR1",
      multiple = FALSE,
      fixed = FALSE
    )
  ),
  regressor = data_extract_spec(
    dataname = "ADSL",
    select = select_spec(
      label = "Select variables:",
      choices = variable_choices(data[["ADSL"]], c("AGE", "SEX", "RACE")),
      selected = c("AGE", "RACE"),
      multiple = TRUE,
      fixed = FALSE
    )
  )
)

# configuration for the same long datasets (same subset)
mod3 <- tm_a_regression(
  label = "Same long datasets (same subset)",
  default_plot_type = 2,
  response = data_extract_spec(
    dataname = "ADTTE",
    select = select_spec(
      label = "Select variable:",
      choices = variable_choices(data[["ADTTE"]], c("AVAL", "CNSR")),
      selected = "AVAL",
      multiple = FALSE,
      fixed = FALSE
    ),
    filter = filter_spec(
      label = "Select parameter:",
      vars = "PARAMCD",
      choices = value_choices(data[["ADTTE"]], "PARAMCD", "PARAM"),
      selected = "PFS",
      multiple = FALSE
    )
  ),
  regressor = data_extract_spec(
    dataname = "ADTTE",
    select = select_spec(
      label = "Select variable:",
      choices = variable_choices(data[["ADTTE"]], c("AGE", "CNSR", "SEX")),
      selected = c("AGE", "CNSR", "SEX"),
      multiple = TRUE
    ),
    filter = filter_spec(
      label = "Select parameter:",
      vars = "PARAMCD",
      choices = value_choices(data[["ADTTE"]], "PARAMCD", "PARAM"),
      selected = "PFS",
      multiple = FALSE
    )
  )
)

# configuration for the wide and long datasets
mod4 <- tm_a_regression(
  label = "Wide and long datasets",
  response = data_extract_spec(
    dataname = "ADLB",
    filter = list(
      filter_spec(
        vars = "PARAMCD",
        choices = value_choices(data[["ADLB"]], "PARAMCD", "PARAM"),
        selected = levels(data[["ADLB"]]$PARAMCD)[2],
        multiple = TRUE,
        label = "Select measurement:"
      ),
      filter_spec(
        vars = "AVISIT",
        choices = levels(data[["ADLB"]]$AVISIT),
        selected = levels(data[["ADLB"]]$AVISIT)[2],
        multiple = TRUE,
        label = "Select visit:"
      )
    ),
    select = select_spec(
      label = "Select variable:",
      choices = "AVAL",
      selected = "AVAL",
      multiple = FALSE,
      fixed = TRUE
    )
  ),
  regressor = data_extract_spec(
    dataname = "ADSL",
    select = select_spec(
      label = "Select variables:",
      choices = variable_choices(data[["ADSL"]], c("BMRKR1", "BMRKR2", "AGE")),
      selected = "AGE",
      multiple = TRUE,
      fixed = FALSE
    )
  )
)

# configuration for the same long datasets (different subsets)
mod5 <- tm_a_regression(
  label = "Same long datasets (different subsets)",
  default_plot_type = 2,
  response = data_extract_spec(
    dataname = "ADLB",
    filter = list(
      filter_spec(
        vars = "PARAMCD",
        choices = value_choices(data[["ADLB"]], "PARAMCD", "PARAM"),
        selected = levels(data[["ADLB"]]$PARAMCD)[1],
        multiple = TRUE,
        label = "Select lab:"
      ),
      filter_spec(
        vars = "AVISIT",
        choices = levels(data[["ADLB"]]$AVISIT),
        selected = levels(data[["ADLB"]]$AVISIT)[1],
        multiple = TRUE,
        label = "Select visit:"
      )
    ),
    select = select_spec(
      choices = "AVAL",
      selected = "AVAL",
      multiple = FALSE,
      fixed = TRUE
    )
  ),
  regressor = data_extract_spec(
    dataname = "ADLB",
    filter = list(
      filter_spec(
        vars = "PARAMCD",
        choices = value_choices(data[["ADLB"]], "PARAMCD", "PARAM"),
        selected = levels(data[["ADLB"]]$PARAMCD)[1],
        multiple = FALSE,
        label = "Select labs:"
      ),
      filter_spec(
        vars = "AVISIT",
        choices = levels(data[["ADLB"]]$AVISIT),
        selected = levels(data[["ADLB"]]$AVISIT)[1],
        multiple = FALSE,
        label = "Select visit:"
      )
    ),
    select = select_spec(
      choices = variable_choices(data[["ADLB"]], c("AVAL", "AGE", "BMRKR1", "BMRKR2", "SEX", "ARM")),
      selected = c("AVAL", "BMRKR1"),
      multiple = TRUE
    )
  )
)

# initialize the app
app <- init(
  data = data,
  modules = modules(
    modules(
      label = "Regression plots",
      mod1,
      mod2,
      mod3,
      mod4,
      mod5
    )
  )
)
```

## 4 - Run the app

A simple `shiny::shinyApp()` call will let you run the app.
Note that app is only displayed when running this code inside an `R` session.

```{r shinyapp, echo=TRUE, results="hide", eval=base::interactive()}
shinyApp(app$ui, app$server, options = list(height = 1024, width = 1024))
```

<img src="images/app-using-regression-plots.png" style = "display: block; margin: 0px; width: 100%"/>

## 5 - Try it out in Shinylive

```{r shinylive_url, echo = FALSE, results = 'asis', eval = requireNamespace("roxy.shinylive", quietly = TRUE)}
code <- paste0(c(
  knitr::knit_code$get("library"),
  knitr::knit_code$get("data"),
  knitr::knit_code$get("app"),
  knitr::knit_code$get("shinyapp")
), collapse = "\n")

url <- roxy.shinylive::create_shinylive_url(code)
cat(sprintf("[Open in Shinylive](%s)\n\n", url))
```

```{r shinylive_iframe, echo = FALSE, out.width = '150%', out.extra = 'style = "position: relative; z-index:1"', eval = requireNamespace("roxy.shinylive", quietly = TRUE) && knitr::is_html_output() && identical(Sys.getenv("IN_PKGDOWN"), "true")}
knitr::include_url(url, height = "800px")
```
