{ "_id": "6a168f48acfb0bcc41d78126", "Type": "Package", "Package": "mmrm", "Title": "Mixed Models for Repeated Measures", "Version": "0.3.17.9000", "Authors@R": "c(\nperson(\"Daniel\", \"Sabanes Bove\", , \"daniel.sabanes_bove@rconis.com\", role = c(\"aut\", \"cre\"),\ncomment = c(ORCID = \"0000-0002-0176-9239\")),\nperson(\"Liming\", \"Li\", , \"liming.li1@astrazeneca.com\", role = \"aut\", comment = c(ORCID = \"0009-0008-6870-0878\")),\nperson(\"Julia\", \"Dedic\", , \"julia.dedic@roche.com\", role = \"aut\"),\nperson(\"Doug\", \"Kelkhoff\", , \"doug.kelkhoff@roche.com\", role = \"aut\"),\nperson(\"Kevin\", \"Kunzmann\", , \"kevin.kunzmann@boehringer-ingelheim.com\", role = \"aut\"),\nperson(\"Brian Matthew\", \"Lang\", , \"brian.lang@msd.com\", role = \"aut\"),\nperson(\"Christian\", \"Stock\", , \"christian.stock@boehringer-ingelheim.com\", role = \"aut\"),\nperson(\"Ya\", \"Wang\", , \"ya.wang10@gilead.com\", role = \"aut\"),\nperson(\"Craig\", \"Gower-Page\", , \"craig.gower-page@roche.com\", role = \"ctb\"),\nperson(\"Dan\", \"James\", , \"dan.james@astrazeneca.com\", role = \"aut\"),\nperson(\"Jonathan\", \"Sidi\", , \"yoni@pinpointstrategies.io\", role = \"aut\"),\nperson(\"Daniel\", \"Leibovitz\", , \"daniel.leibovitz@roche.com\", role = \"aut\"),\nperson(\"Daniel D.\", \"Sjoberg\", , \"sjobergd@gene.com\", role = \"aut\",\ncomment = c(ORCID = \"0000-0003-0862-2018\")),\nperson(\"Nikolas Ivan\", \"Krieger\", , \"nikolas.krieger@experis.com\", role = \"aut\",\ncomment = c(ORCID = \"0000-0002-4581-3545\")),\nperson(\"Lukas A.\", \"Widmer\", role = \"ctb\",\ncomment = c(ORCID = \"0000-0003-1471-3493\")),\nperson(\"Boehringer Ingelheim Ltd.\", role = c(\"cph\", \"fnd\")),\nperson(\"Gilead Sciences, Inc.\", role = c(\"cph\", \"fnd\")),\nperson(\"F. Hoffmann-La Roche AG\", role = c(\"cph\", \"fnd\")),\nperson(\"Merck Sharp & Dohme, Inc.\", role = c(\"cph\", \"fnd\")),\nperson(\"AstraZeneca plc\", role = c(\"cph\", \"fnd\")),\nperson(\"inferential.biostatistics GmbH\", role = c(\"cph\", \"fnd\"))\n)", "Description": "Mixed models for repeated measures (MMRM) are a popular\nchoice for analyzing longitudinal continuous outcomes in\nrandomized clinical trials and beyond; see Cnaan, Laird and\nSlasor (1997)\n\nfor a tutorial and Mallinckrodt, Lane, Schnell, Peng and\nMancuso (2008) for a review.\nThis package implements MMRM based on the marginal linear model\nwithout random effects using Template Model Builder ('TMB')\nwhich enables fast and robust model fitting. Users can specify\na variety of covariance matrices, weight observations, fit\nmodels with restricted or standard maximum likelihood\ninference, perform hypothesis testing with Satterthwaite or\nKenward-Roger adjustment, and extract least square means\nestimates by using 'emmeans'.", "License": "Apache License 2.0", "URL": "https://openpharma.github.io/mmrm/", "BugReports": "https://github.com/openpharma/mmrm/issues", "VignetteBuilder": "knitr", "RdMacros": "Rdpack", "Config/testthat/edition": "3", "Encoding": "UTF-8", "Language": "en-US", "LazyData": "true", "NeedsCompilation": "yes", "Roxygen": "list(markdown = TRUE)", "RoxygenNote": "7.3.3", "Collate": "'between-within.R' 'catch-routine-registration.R'\n'component.R' 'cov_struct.R' 'data.R' 'empirical.R' 'fit.R'\n'kenwardroger.R' 'mmrm-methods.R' 'mmrm-package.R' 'utils.R'\n'residual.R' 'utils-nse.R' 'utils-formula.R' 'satterthwaite.R'\n'skipping.R' 'tidiers.R' 'testing.R' 'tmb-methods.R' 'tmb.R'\n'interop-emmeans.R' 'interop-parsnip.R' 'interop-car.R' 'zzz.R'", "Config/pak/sysreqs": "cmake make libicu-dev libuv1-dev", "Repository": "https://pharmaverse.r-universe.dev", "Date/Publication": "2026-04-27 06:13:12 UTC", "RemoteUrl": "https://github.com/openpharma/mmrm", "RemoteRef": "HEAD", "RemoteSha": "233c1c472392ec1ce832d027154b1682a5d13610", "Packaged": { "Date": "2026-05-27 06:12:39 UTC", "User": "root" }, "Author": "Daniel Sabanes Bove [aut, cre] (ORCID:\n),\nLiming Li [aut] (ORCID: ),\nJulia Dedic [aut],\nDoug Kelkhoff [aut],\nKevin Kunzmann [aut],\nBrian Matthew Lang [aut],\nChristian Stock [aut],\nYa Wang [aut],\nCraig Gower-Page [ctb],\nDan James [aut],\nJonathan Sidi [aut],\nDaniel Leibovitz [aut],\nDaniel D. Sjoberg [aut] (ORCID:\n),\nNikolas Ivan Krieger [aut] (ORCID:\n),\nLukas A. Widmer [ctb] (ORCID: ),\nBoehringer Ingelheim Ltd. [cph, fnd],\nGilead Sciences, Inc. [cph, fnd],\nF. Hoffmann-La Roche AG [cph, fnd],\nMerck Sharp & Dohme, Inc. 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