{
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  "Package": "gemtcPlus",
  "Type": "Package",
  "Title": "Provides a suite of extension functions for NMA using the\n`gemtc` package",
  "Version": "1.0.0",
  "Authors@R": "c(\nperson(\"Sandro\", \"Gsteiger\", email = \"sandro.gsteiger@roche.com\", role = c(\"aut\", \"cre\")),\nperson(\"Nick\", \"Howlett\", role = \"aut\"),\nperson(\"Beth\", \"Ashlee\", role = \"aut\"),\nperson(\"F. Hoffmann La Roche Ltd\", role = c(\"cph\"))\n)",
  "Description": "Functions for generating outputs: tables and plots for NMA\nreports.",
  "License": "Apache License (>= 2)",
  "Encoding": "UTF-8",
  "LazyData": "true",
  "RoxygenNote": "7.3.2",
  "VignetteBuilder": "knitr",
  "Config/pak/sysreqs": "cmake libglpk-dev make jags libicu-dev libuv1-dev\nlibxml2-dev libssl-dev libx11-dev",
  "Repository": "https://pharmaverse.r-universe.dev",
  "Date/Publication": "2025-04-24 13:52:00 UTC",
  "RemoteUrl": "https://github.com/Roche/gemtcPlus",
  "RemoteRef": "HEAD",
  "RemoteSha": "55fede33799202381160eecddd8caec52c08c004",
  "NeedsCompilation": "no",
  "Packaged": {
    "Date": "2026-05-27 06:42:35 UTC",
    "User": "root"
  },
  "Author": "Sandro Gsteiger [aut, cre],\nNick Howlett [aut],\nBeth Ashlee [aut],\nF. Hoffmann La Roche Ltd [cph]",
  "Maintainer": "Sandro Gsteiger <sandro.gsteiger@roche.com>",
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  "_published": "2026-05-27T06:46:30.398Z",
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  "_assets": [
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    "extra/gemtcPlus.html",
    "extra/readme.html",
    "extra/readme.md",
    "manual.pdf"
  ],
  "_cranurl": false,
  "_exports": [
    "bth_prior",
    "create_template",
    "get_fp_1o",
    "get_fp_1o_GoF",
    "get_fp_1o_HR",
    "get_fp_1o_S",
    "get_fp_2o",
    "get_fp_2o_GoF",
    "get_fp_2o_HR",
    "get_fp_2o_S",
    "get_fp_comparison",
    "get_fp_contrasts",
    "get_fp_corrs",
    "get_fp_elements",
    "get_fp_GoF",
    "get_fp_HR",
    "get_fp_S",
    "get_jags_info",
    "get_mtc_allVsNew",
    "get_mtc_newVsAll",
    "get_mtc_probBetter",
    "get_mtc_sum",
    "get_nw_fromto",
    "get_pw_segments",
    "get_pwe_comparison",
    "get_pwe_contrasts",
    "get_pwe_conv_diag",
    "get_pwe_elements",
    "get_pwe_GoF",
    "get_pwe_S",
    "get_segments",
    "groupedTTE_fp_pre_proc",
    "groupedTTE_pwe_pre_proc",
    "list_BUGS",
    "match_args_to_func",
    "mtc.prob.better.table",
    "nma_fit",
    "nma_pre_proc",
    "plan_binary",
    "plan_fp",
    "plan_hr",
    "plan_pwe",
    "plot_fp_HR",
    "plot_mtc_forest",
    "process_binary",
    "process_gsd",
    "process_hr",
    "pwe_Hu",
    "pwe_S"
  ],
  "_datasets": [
    {
      "name": "binary_data",
      "title": "",
      "object": "binary_data",
      "class": [
        "tbl_df",
        "tbl",
        "data.frame"
      ],
      "fields": [
        "study",
        "treatment",
        "n",
        "x"
      ],
      "rows": 16,
      "table": true,
      "tojson": true
    },
    {
      "name": "grouped_KM",
      "title": "",
      "object": "grouped_KM",
      "class": [
        "data.frame"
      ],
      "fields": [
        "study",
        "treatment",
        "interval",
        "t.start",
        "t.end",
        "n.event",
        "n.censored",
        "c.event",
        "c.censored",
        "n.rm",
        "n.risk",
        "h",
        "S.end",
        "S.start"
      ],
      "rows": 675,
      "table": true,
      "tojson": true
    },
    {
      "name": "grouped_TTE",
      "title": "",
      "object": "grouped_TTE",
      "class": [
        "data.frame"
      ],
      "fields": [
        "study",
        "treatment",
        "t.start",
        "t.end",
        "n.event",
        "n.censored",
        "n.risk"
      ],
      "rows": 675,
      "table": true,
      "tojson": true
    },
    {
      "name": "hr_data",
      "title": "",
      "object": "hr_data",
      "class": [
        "data.frame"
      ],
      "fields": [
        "study",
        "new",
        "ref",
        "lhr",
        "lhrse",
        "hr",
        "ci_lo",
        "ci_up"
      ],
      "rows": 7,
      "table": true,
      "tojson": true
    }
  ],
  "_help": [
    {
      "page": "bth_prior",
      "title": "Creates a fractional polynomial model plan",
      "topics": [
        "bth_prior"
      ]
    },
    {
      "page": "create_jags_init",
      "title": "create_jags_init. Helper function to create jags init list dependant on length on chains provided",
      "topics": [
        "create_jags_init"
      ]
    },
    {
      "page": "create_template",
      "title": "Creates a minimal project template for selected model type",
      "topics": [
        "create_template"
      ]
    },
    {
      "page": "extract_BUGS_file",
      "title": "Helper function to extract BUGS files for given input parameters",
      "topics": [
        "extract_BUGS_file"
      ]
    },
    {
      "page": "gemtcPlus",
      "title": "gemtcPlus: A package for performing NMA in R",
      "topics": [
        "gemtcPlus-package",
        "gemtcPlus"
      ]
    },
    {
      "page": "get_fp_1o",
      "title": "First order fractional polynomial",
      "topics": [
        "get_fp_1o"
      ]
    },
    {
      "page": "get_fp_1o_GoF",
      "title": "Calculate the study and arm level survivor functions estimates from a 1st order fractional polynomial NMA. These estimates provide the basis for a goodness-of-fit graph when plotted along with the input data.",
      "topics": [
        "get_fp_1o_GoF"
      ]
    },
    {
      "page": "get_fp_1o_HR",
      "title": "Calculate the time-dependent hazard ratios obtained from fitting a first order fractional polynomial model.",
      "topics": [
        "get_fp_1o_HR"
      ]
    },
    {
      "page": "get_fp_1o_S",
      "title": "Calculate the survivor functions estimated in a 1st order fractional polynomial NMA model. The absolute S(t) estimates combining the estimated baseline survival from a reference trial (in the NMA) with the fractional polynomial (log)hazard ratio estimates to construct the S(t) functions for each treatment.",
      "topics": [
        "get_fp_1o_S"
      ]
    },
    {
      "page": "get_fp_2o",
      "title": "Second order fractional polynomial",
      "topics": [
        "get_fp_2o"
      ]
    },
    {
      "page": "get_fp_2o_GoF",
      "title": "Calculate the study and arm level survivor functions estimates from a 2nd order fractional polynomial NMA. These estimates provide the basis for a goodness-of-fit graph when plotted along with the input data.",
      "topics": [
        "get_fp_2o_GoF"
      ]
    },
    {
      "page": "get_fp_2o_HR",
      "title": "Calculate the time-dependent hazard ratios obtained from fitting a second order fractional polynomial model.",
      "topics": [
        "get_fp_2o_HR"
      ]
    },
    {
      "page": "get_fp_2o_S",
      "title": "Calculate the survivor functions estimated in a 2nd order fractional polynomial NMA model. The absolute S(t) estimates combining the estimated baseline survival from a reference trial (in the NMA) with the fractional polynomial (log)hazard ratio estimates to construct the S(t) functions for each treatment.",
      "topics": [
        "get_fp_2o_S"
      ]
    },
    {
      "page": "get_fp_comparison",
      "title": "Extract model information and fit statistics from a list of fractional polynomial NMAs.",
      "topics": [
        "get_fp_comparison"
      ]
    },
    {
      "page": "get_fp_contrasts",
      "title": "Extract the treatment contrasts vs the reference in the network",
      "topics": [
        "get_fp_contrasts"
      ]
    },
    {
      "page": "get_fp_corrs",
      "title": "Calculate correlations between the contrast estimates for multi-dimensional effect estimates for all treatments in a FP NMA.",
      "topics": [
        "get_fp_corrs"
      ]
    },
    {
      "page": "get_fp_elements",
      "title": "Extract model information and fit statistics from NMA fit in jags of a fractional polynomial model.",
      "topics": [
        "get_fp_elements"
      ]
    },
    {
      "page": "get_fp_GoF",
      "title": "Calculate the study and arm level survivor functions estimates from a fractional polynomial NMA. These estimates provide the basis for a goodness-of-fit graph when plotted along with the input data.",
      "topics": [
        "get_fp_GoF"
      ]
    },
    {
      "page": "get_fp_HR",
      "title": "Calculate the time-dependent hazard ratios obtained from fitting a fractional polynomial model (first or second order).",
      "topics": [
        "get_fp_HR"
      ]
    },
    {
      "page": "get_fp_S",
      "title": "Calculate the survivor functions estimated in a fractional polynomial NMA model. The absolute S(t) estimates combining the estimated baseline survival from a reference trial (in the NMA) with the fractional polynomial (log)hazard ratio estimates to construct the S(t) functions for each treatment.",
      "topics": [
        "get_fp_S"
      ]
    },
    {
      "page": "get_jags_info",
      "title": "Utility function to return jags data and model for reporting (e.g. in appendix)",
      "topics": [
        "get_jags_info"
      ]
    },
    {
      "page": "get_mtc_allVsNew",
      "title": "Utility function to extract effect estimates \"other treatments vs new\" from gemtc fit.",
      "topics": [
        "get_mtc_allVsNew"
      ]
    },
    {
      "page": "get_mtc_newVsAll",
      "title": "Utility function to extract effect estimates \"new vs other treatments\" from gemtc fit.",
      "topics": [
        "get_mtc_newVsAll"
      ]
    },
    {
      "page": "get_mtc_probBetter",
      "title": "Utility function to extract probabilities of new treatment being better from gemtc fit (e.g. P(HR<1) for HRs new vs other).",
      "topics": [
        "get_mtc_probBetter"
      ]
    },
    {
      "page": "get_mtc_sum",
      "title": "Utility function to extract summary stats from mtc.result object.",
      "topics": [
        "get_mtc_sum"
      ]
    },
    {
      "page": "get_nw_fromto",
      "title": "Extract edges information (\"from-to matrix\") from network data frame.",
      "topics": [
        "get_nw_fromto"
      ]
    },
    {
      "page": "get_pw_segments",
      "title": "Utility function to get segments (as character strings) from vector with cutpoints",
      "topics": [
        "get_pw_segments"
      ]
    },
    {
      "page": "get_pwe_comparison",
      "title": "Extract model information and fit statistics from a list of piecewise-exponential NMA fits.",
      "topics": [
        "get_pwe_comparison"
      ]
    },
    {
      "page": "get_pwe_contrasts",
      "title": "Utility function to extract HR estimates from piece-wise exponential model fit in (format needed for ggplot)",
      "topics": [
        "get_pwe_contrasts"
      ]
    },
    {
      "page": "get_pwe_conv_diag",
      "title": "Utility function: convergence diagnostics for piece-wise constant models",
      "topics": [
        "get_pwe_conv_diag"
      ]
    },
    {
      "page": "get_pwe_elements",
      "title": "Extract model information and fit statistics from NMA fit in jags of a piecewise-exponential model.",
      "topics": [
        "get_pwe_elements"
      ]
    },
    {
      "page": "get_pwe_GoF",
      "title": "Calculate the survivor function estimates for each study and arm. Calculate also the observed survival curves from the binned KM data to compare observed and estimated survivor functions.",
      "topics": [
        "get_pwe_GoF"
      ]
    },
    {
      "page": "get_pwe_S",
      "title": "Calculate the survivor functions estimated in piecewise-constant NMA model. The absolute S(t) estimates combining the estimated baseline survival from a reference trial (in the NMA) with the piecewise-constant hazard ratio estimates to construct the S(t) functions for each treatment.",
      "topics": [
        "get_pwe_S"
      ]
    },
    {
      "page": "get_segments",
      "title": "Utility function to get segments (as character strings) from vector with cutpoints",
      "topics": [
        "get_segments"
      ]
    },
    {
      "page": "groupedTTE_fp_pre_proc",
      "title": "Utility function for pre-processing: prepare jags input data for FP model.",
      "topics": [
        "groupedTTE_fp_pre_proc"
      ]
    },
    {
      "page": "groupedTTE_pwe_pre_proc",
      "title": "Utility function for pre-processing: prepare jags input data for PWE model.",
      "topics": [
        "groupedTTE_pwe_pre_proc"
      ]
    },
    {
      "page": "list_BUGS",
      "title": "Lists all available model files inside the inst directory",
      "topics": [
        "list_BUGS"
      ]
    },
    {
      "page": "match_args_to_func",
      "title": "Helper function to extract named elements from a list to match the arguments of supplied function",
      "topics": [
        "match_args_to_func"
      ]
    },
    {
      "page": "mtc.prob.better.table",
      "title": "Utility function providing pairwise probability of being better (col vs row). (Adapted from gemtc::relative.effect.table()).",
      "topics": [
        "mtc.prob.better.table"
      ]
    },
    {
      "page": "nma_fit",
      "title": "Takes input data and a model plan and passes to the model engine specified.  Current supported engines are the `gemtc` package (using mtc.model & mtc.run) or `rjags` (using jags and dic.samples functions)",
      "topics": [
        "nma_fit"
      ]
    },
    {
      "page": "nma_pre_proc",
      "title": "NMA data pre-processing",
      "topics": [
        "nma_pre_proc"
      ]
    },
    {
      "page": "plan_binary",
      "title": "Creates a model plan for binary data",
      "topics": [
        "plan_binary"
      ]
    },
    {
      "page": "plan_fp",
      "title": "Creates a fractional polynomial model plan",
      "topics": [
        "plan_fp"
      ]
    },
    {
      "page": "plan_hr",
      "title": "Creates a model plan for hazard ratio",
      "topics": [
        "plan_hr"
      ]
    },
    {
      "page": "plan_pwe",
      "title": "Creates a fractional polynomial model plan",
      "topics": [
        "plan_pwe"
      ]
    },
    {
      "page": "plot_fp_HR",
      "title": "Produce ggplot from HR values in data.frame (medians vs time for several trts, all in one plot)",
      "topics": [
        "plot_fp_HR"
      ]
    },
    {
      "page": "plot_mtc_forest",
      "title": "Utility function to do forest plot from data.frame with effect estimates.",
      "topics": [
        "plot_mtc_forest"
      ]
    },
    {
      "page": "process_binary",
      "title": "Transforms binary data",
      "topics": [
        "process_binary"
      ]
    },
    {
      "page": "process_gsd",
      "title": "Transforms grouped survival data",
      "topics": [
        "process_gsd"
      ]
    },
    {
      "page": "process_hr",
      "title": "Transforms hazard ratio data",
      "topics": [
        "process_hr"
      ]
    },
    {
      "page": "pwe_Hu",
      "title": "Calculate the cumulative hazard over [0, tmax] from piecewise constant model.",
      "topics": [
        "pwe_Hu"
      ]
    },
    {
      "page": "pwe_S",
      "title": "Calculate the survivor function S(t) from a piecewise exponential model.",
      "topics": [
        "pwe_S"
      ]
    }
  ],
  "_readme": "https://github.com/Roche/gemtcPlus/raw/HEAD/README.md",
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