{"SOC":"Blood and lymphatic system disorders","TERM":"Anemia","Grade_1":"Hemoglobin (Hgb) <LLN - 10.0 g/dL; <LLN - 6.2 mmol/L; <LLN - 100 g/L","Grade_2":"Hgb <10.0 - 8.0 g/dL; <6.2 - 4.9 mmol/L; <100 - 80g/L","Grade_3":"Hgb <8.0 g/dL; <4.9 mmol/L; <80 g/L; transfusion indicated","Grade_4":"Life-threatening consequences; urgent intervention indicated","Grade_5":"Death","Definition":"A disorder characterized by an reduction in the amount of hemoglobin in 100 ml of blood. Signs and symptoms of anemia may include pallor of the skin and mucous membranes, shortness of breath, palpitations of the heart, soft systolic murmurs, lethargy, and fatigability.","GRADE_CRITERIA_CODE":"case_when(  is.na(AVAL) ~ NA_character_,  signif(AVAL, signif_dig) < 80 ~ \"3\",  signif(AVAL, signif_dig) < 100 ~ \"2\",  is.na(ANRLO) ~ NA_character_,  signif(AVAL, signif_dig) < signif(ANRLO, signif_dig) ~ \"1\",  signif(AVAL, signif_dig) >= signif(ANRLO, signif_dig) ~ \"0\"  )","SI_UNIT_CHECK":"g/L","VAR_CHECK":"AVAL, ANRLO","DIRECTION":"L"}
{"SOC":"Blood and lymphatic system disorders","TERM":"Leukocytosis","Grade_1":"-","Grade_2":"-","Grade_3":">100,000/mm3","Grade_4":"Clinical manifestations of leucostasis; urgent intervention indicated","Grade_5":"Death","Definition":"A disorder characterized by laboratory test results that indicate an increased number of white blood cells in the blood.","GRADE_CRITERIA_CODE":"case_when(  is.na(AVAL) ~ NA_character_,  signif(AVAL, signif_dig) > 100 ~ \"3\",  signif(AVAL, signif_dig) <= 100 ~ \"0\"  )","SI_UNIT_CHECK":"10^9/L","VAR_CHECK":"AVAL","DIRECTION":"H"}
{"SOC":"Investigations","TERM":"Activated partial thromboplastin time prolonged","Grade_1":">ULN - 1.5 x ULN","Grade_2":">1.5 - 2.5 x ULN","Grade_3":">2.5 x ULN; hemorrhage","Grade_4":"-","Grade_5":"-","Definition":"An abnormal laboratory test result in which the partial thromboplastin time is found to be greater than the control value. As a possible indicator of coagulopathy, a prolonged partial thromboplastin time (PTT) may occur in a variety of diseases and disorders, both primary and related to treatment.","GRADE_CRITERIA_CODE":"case_when(  is.na(AVAL) | is.na(ANRHI) ~ NA_character_,  signif(AVAL, signif_dig) >  signif(2.5*ANRHI, signif_dig) ~ \"3\",  signif(AVAL, signif_dig) > signif(1.5*ANRHI, signif_dig) ~ \"2\",  signif(AVAL, signif_dig) > signif(ANRHI, signif_dig) ~ \"1\",  signif(AVAL, signif_dig) <= signif(ANRHI, signif_dig) ~ \"0\"  )","VAR_CHECK":"AVAL, ANRHI","DIRECTION":"H"}
{"SOC":"Investigations","TERM":"Alanine aminotransferase increased","Grade_1":">ULN - 3.0 x ULN","Grade_2":">3.0 - 5.0 x ULN","Grade_3":">5.0 - 20.0 x ULN","Grade_4":">20.0 x ULN","Grade_5":"-","Definition":"A finding based on laboratory test results that indicate an increase in the level of alanine aminotransferase (ALT or SGPT) in the blood specimen.","GRADE_CRITERIA_CODE":"case_when(  is.na(AVAL) | is.na(ANRHI) ~ NA_character_,  signif(AVAL, signif_dig) >  signif(20*ANRHI, signif_dig) ~ \"4\",  signif(AVAL, signif_dig) >  signif(5*ANRHI, signif_dig) ~ \"3\",  signif(AVAL, signif_dig) > signif(3*ANRHI, signif_dig) ~ \"2\",  signif(AVAL, signif_dig) > signif(ANRHI, signif_dig) ~ \"1\",  signif(AVAL, signif_dig) <= signif(ANRHI, signif_dig) ~ \"0\"  )","VAR_CHECK":"AVAL, ANRHI","DIRECTION":"H"}
{"SOC":"Investigations","TERM":"Alkaline phosphatase increased","Grade_1":">ULN - 2.5 x ULN","Grade_2":">2.5 - 5.0 x ULN","Grade_3":">5.0 - 20.0 x ULN","Grade_4":">20.0 x ULN","Grade_5":"-","Definition":"A finding based on laboratory test results that indicate an increase in the level of alkaline phosphatase in a blood specimen.","GRADE_CRITERIA_CODE":"case_when(  is.na(AVAL) | is.na(ANRHI) ~ NA_character_,  signif(AVAL, signif_dig) >  signif(20*ANRHI, signif_dig) ~ \"4\",  signif(AVAL, signif_dig) >  signif(5*ANRHI, signif_dig) ~ \"3\",  signif(AVAL, signif_dig) > signif(2.5*ANRHI, signif_dig) ~ \"2\",  signif(AVAL, signif_dig) > signif(ANRHI, signif_dig) ~ \"1\",  signif(AVAL, signif_dig) <= signif(ANRHI, signif_dig) ~ \"0\"  )","VAR_CHECK":"AVAL, ANRHI","DIRECTION":"H"}
{"SOC":"Investigations","TERM":"Aspartate aminotransferase increased","Grade_1":">ULN - 3.0 x ULN","Grade_2":">3.0 - 5.0 x ULN","Grade_3":">5.0 - 20.0 x ULN","Grade_4":">20.0 x ULN","Grade_5":"-","Definition":"A finding based on laboratory test results that indicate an increase in the level of aspartate aminotransferase (AST or SGOT) in a blood specimen.","GRADE_CRITERIA_CODE":"case_when(  is.na(AVAL) | is.na(ANRHI) ~ NA_character_,  signif(AVAL, signif_dig) >  signif(20*ANRHI, signif_dig) ~ \"4\",  signif(AVAL, signif_dig) >  signif(5*ANRHI, signif_dig) ~ \"3\",  signif(AVAL, signif_dig) > signif(3*ANRHI, signif_dig) ~ \"2\",  signif(AVAL, signif_dig) > signif(ANRHI, signif_dig) ~ \"1\",  signif(AVAL, signif_dig) <= signif(ANRHI, signif_dig) ~ \"0\"  )","VAR_CHECK":"AVAL, ANRHI","DIRECTION":"H"}
{"SOC":"Investigations","TERM":"Blood bilirubin increased","Grade_1":">ULN - 1.5 x ULN","Grade_2":">1.5 - 3.0 x ULN","Grade_3":">3.0 - 10.0 x ULN","Grade_4":">10.0 x ULN","Grade_5":"-","Definition":"A finding based on laboratory test results that indicate an abnormally high level of bilirubin in the blood. Excess bilirubin is associated with jaundice.","GRADE_CRITERIA_CODE":"case_when(  is.na(AVAL) | is.na(ANRHI) ~ NA_character_,  signif(AVAL, signif_dig) >  signif(10*ANRHI, signif_dig) ~ \"4\",  signif(AVAL, signif_dig) >  signif(3*ANRHI, signif_dig) ~ \"3\",  signif(AVAL, signif_dig) > signif(1.5*ANRHI, signif_dig) ~ \"2\",  signif(AVAL, signif_dig) > signif(ANRHI, signif_dig) ~ \"1\",  signif(AVAL, signif_dig) <= signif(ANRHI, signif_dig) ~ \"0\"  )","VAR_CHECK":"AVAL, ANRHI","DIRECTION":"H"}
{"SOC":"Investigations","TERM":"CD4 lymphocytes decreased","Grade_1":"<LLN - 500/mm3; <LLN - 0.5 x 10e9 /L","Grade_2":"<500 - 200/mm3; <0.5 - 0.2 x 10e9 /L","Grade_3":"<200 - 50/mm3; <0.2 x 0.05 - 10e9 /L","Grade_4":"<50/mm3; <0.05 x 10e9 /L","Grade_5":"-","Definition":"A finding based on laboratory test results that indicate an decrease in levels of CD4 lymphocytes in a blood specimen.","GRADE_CRITERIA_CODE":"case_when(  is.na(AVAL) ~ NA_character_,  signif(AVAL, signif_dig) < 0.05 ~ \"4\",  signif(AVAL, signif_dig) < 0.2 ~ \"3\",  signif(AVAL, signif_dig) < 0.5 ~ \"2\",  is.na(ANRLO) ~ NA_character_,  signif(AVAL, signif_dig) < signif(ANRLO, signif_dig) ~ \"1\",  signif(AVAL, signif_dig) >= signif(ANRLO, signif_dig) ~ \"0\"  )","SI_UNIT_CHECK":"10^9/L","VAR_CHECK":"AVAL, ANRLO","DIRECTION":"L"}
{"SOC":"Investigations","TERM":"Cholesterol high","Grade_1":">ULN - 300 mg/dL; >ULN - 7.75 mmol/L","Grade_2":">300 - 400 mg/dL; >7.75 - 10.34 mmol/L","Grade_3":">400 - 500 mg/dL; >10.34 - 12.92 mmol/L","Grade_4":">500 mg/dL; >12.92 mmol/L","Grade_5":"-","Definition":"A finding based on laboratory test results that indicate higher than normal levels of cholesterol in a blood specimen.","GRADE_CRITERIA_CODE":"case_when(  is.na(AVAL) ~ NA_character_,  signif(AVAL, signif_dig) > 12.92 ~ \"4\",  signif(AVAL, signif_dig) > 10.34 ~ \"3\",  signif(AVAL, signif_dig) > 7.75 ~ \"2\",  is.na(ANRHI) ~ NA_character_,  signif(AVAL, signif_dig) > signif(ANRHI, signif_dig) ~ \"1\",  signif(AVAL, signif_dig) <= signif(ANRHI, signif_dig) ~ \"0\"  )","SI_UNIT_CHECK":"mmol/L","VAR_CHECK":"AVAL, ANRHI","DIRECTION":"H"}
{"SOC":"Investigations","TERM":"CPK increased","Grade_1":">ULN - 2.5 x ULN","Grade_2":">2.5 x ULN - 5 x ULN","Grade_3":">5 x ULN - 10 x ULN","Grade_4":">10 x ULN","Grade_5":"-","Definition":"A finding based on laboratory test results that indicate an increase in levels of creatine phosphokinase in a blood specimen.","GRADE_CRITERIA_CODE":"case_when(  is.na(AVAL) | is.na(ANRHI) ~ NA_character_,  signif(AVAL, signif_dig) >  signif(10*ANRHI, signif_dig) ~ \"4\",  signif(AVAL, signif_dig) >  signif(5*ANRHI, signif_dig) ~ \"3\",  signif(AVAL, signif_dig) > signif(2.5*ANRHI, signif_dig) ~ \"2\",  signif(AVAL, signif_dig) > signif(ANRHI, signif_dig) ~ \"1\",  signif(AVAL, signif_dig) <= signif(ANRHI, signif_dig) ~ \"0\"  )","VAR_CHECK":"AVAL, ANRHI","DIRECTION":"H"}
{"SOC":"Investigations","TERM":"Creatinine increased","Grade_1":">1 - 1.5 x baseline; >ULN - 1.5 x ULN","Grade_2":">1.5 - 3.0 x baseline; >1.5 - 3.0 x ULN","Grade_3":">3.0 baseline; >3.0 - 6.0 x ULN","Grade_4":">6.0 x ULN","Grade_5":"-","Definition":"A finding based on laboratory test results that indicate increased levels of creatinine in a biological specimen.","GRADE_CRITERIA_CODE":"case_when(  is.na(AVAL) ~ NA_character_,  !is.na(ANRHI) & signif(AVAL, signif_dig) >  signif(6*ANRHI, signif_dig) ~ \"4\",  !is.na(ANRHI) & signif(AVAL, signif_dig) >  signif(3*ANRHI, signif_dig) ~ \"3\",  !is.na(BASE) & signif(AVAL, signif_dig) > signif(3*BASE, signif_dig) ~ \"3\",  !is.na(ANRHI) & signif(AVAL, signif_dig) > signif(1.5*ANRHI, signif_dig) ~ \"2\",  !is.na(BASE) & signif(AVAL, signif_dig) > signif(1.5*BASE, signif_dig) ~ \"2\",  !is.na(ANRHI) & signif(AVAL, signif_dig) > signif(ANRHI, signif_dig) ~ \"1\",  !is.na(BASE) & signif(AVAL, signif_dig) > signif(BASE, signif_dig) ~ \"1\",  !is.na(ANRHI) & signif(AVAL, signif_dig) <= signif(ANRHI, signif_dig) & !is.na(BASE) & signif(AVAL, signif_dig) <= signif(BASE, signif_dig) ~ \"0\",  is.na(ANRHI) | is.na(BASE) ~ NA_character_  )","VAR_CHECK":"AVAL, ANRHI, BASE","DIRECTION":"H"}
{"SOC":"Investigations","TERM":"Fibrinogen decreased","Grade_1":"<1.0 - 0.75 x LLN or <25% decrease from baseline","Grade_2":"<0.75 - 0.5 x LLN or 25 - <50% decrease from baseline","Grade_3":"<0.5 - 0.25 x LLN or 50 - <75% decrease from baseline","Grade_4":"<0.25 x LLN or 75% decrease from baseline or absolute value <50 mg/dL","Grade_5":"-","Definition":"A finding based on laboratory test results that indicate an decrease in levels of fibrinogen in a blood specimen.","GRADE_CRITERIA_CODE":"case_when(  is.na(AVAL) ~ NA_character_,  !is.na(ANRLO) & signif(AVAL, signif_dig) <  signif(0.25*ANRLO, signif_dig) ~ \"4\",  !is.na(PCHG) & signif(PCHG, signif_dig) <=  -75 ~ \"4\",  signif(AVAL, signif_dig) <  0.5 ~ \"4\",  !is.na(ANRLO) & signif(AVAL, signif_dig) <  signif(0.5*ANRLO, signif_dig) ~ \"3\",  !is.na(PCHG) & signif(PCHG, signif_dig) <=  -50 ~ \"3\",  !is.na(ANRLO) & signif(AVAL, signif_dig) <  signif(0.75*ANRLO, signif_dig) ~ \"2\",  !is.na(PCHG) & signif(PCHG, signif_dig) <=  -25 ~ \"2\",  !is.na(ANRLO) & signif(AVAL, signif_dig) <  signif(ANRLO, signif_dig) ~ \"1\",  !is.na(PCHG) & signif(PCHG, signif_dig) <  0 ~ \"1\",  !is.na(ANRLO) & signif(AVAL, signif_dig) >= signif(ANRLO, signif_dig) & !is.na(PCHG) & signif(PCHG, signif_dig) >= 0 ~ \"0\",  is.na(ANRLO) | is.na(PCHG) ~ NA_character_  )","SI_UNIT_CHECK":"g/L","VAR_CHECK":"AVAL, ANRLO, PCHG","DIRECTION":"L"}
{"SOC":"Investigations","TERM":"GGT increased","Grade_1":">ULN - 2.5 x ULN","Grade_2":">2.5 - 5.0 x ULN","Grade_3":">5.0 - 20.0 x ULN","Grade_4":">20.0 x ULN","Grade_5":"-","Definition":"A finding based on laboratory test results that indicate higher than normal levels of the enzyme gamma-glutamyltransferase in the blood specimen. GGT (gamma-glutamyltransferase ) catalyzes the transfer of a gamma glutamyl group from a gamma glutamyl peptide to another peptide, amino acids or water.","GRADE_CRITERIA_CODE":"case_when(  is.na(AVAL) | is.na(ANRHI) ~ NA_character_,  signif(AVAL, signif_dig) >  signif(20*ANRHI, signif_dig) ~ \"4\",  signif(AVAL, signif_dig) >  signif(5*ANRHI, signif_dig) ~ \"3\",  signif(AVAL, signif_dig) > signif(2.5*ANRHI, signif_dig) ~ \"2\",  signif(AVAL, signif_dig) > signif(ANRHI, signif_dig) ~ \"1\",  signif(AVAL, signif_dig) <= signif(ANRHI, signif_dig) ~ \"0\"  )","VAR_CHECK":"AVAL, ANRHI","DIRECTION":"H"}
{"SOC":"Investigations","TERM":"Haptoglobin decreased","Grade_1":"<LLN","Grade_2":"-","Grade_3":"-","Grade_4":"-","Grade_5":"-","Definition":"A finding based on laboratory test results that indicate an decrease in levels of haptoglobin in a blood specimen.","GRADE_CRITERIA_CODE":"case_when(  is.na(AVAL) | is.na(ANRLO) ~ NA_character_,  signif(AVAL, signif_dig) < signif(ANRLO, signif_dig) ~ \"1\",  signif(AVAL, signif_dig) >= signif(ANRLO, signif_dig) ~ \"0\"  )","VAR_CHECK":"AVAL, ANRLO","DIRECTION":"L"}
{"SOC":"Investigations","TERM":"Hemoglobin increased","Grade_1":"Increase in >0 - 2 gm/dL above ULN or above baseline if baseline is above ULN","Grade_2":"Increase in >2 - 4 gm/dL above ULN or above baseline if baseline is above ULN","Grade_3":"Increase in >4 gm/dL above ULN or above baseline if baseline is above ULN","Grade_4":"-","Grade_5":"-","Definition":"A finding based on laboratory test results that indicate increased levels of hemoglobin in a biological specimen.","GRADE_CRITERIA_CODE":"case_when(  is.na(AVAL) | is.na(ANRHI) ~ NA_character_,  !is.na(BASE) & signif(BASE, signif_dig) > signif(ANRHI, signif_dig) & signif(AVAL, signif_dig) > signif(BASE + 40, signif_dig) ~ \"3\",  !is.na(BASE) & signif(BASE, signif_dig) <=  signif(ANRHI, signif_dig) & signif(AVAL, signif_dig) > signif(ANRHI + 40, signif_dig) ~ \"3\",  is.na(BASE) & signif(AVAL, signif_dig) > signif(ANRHI + 40, signif_dig) ~ \"3\",  !is.na(BASE) & signif(BASE, signif_dig) > signif(ANRHI, signif_dig) & signif(AVAL, signif_dig) > signif(BASE + 20, signif_dig) ~ \"2\",  !is.na(BASE) & signif(BASE, signif_dig) <=  signif(ANRHI, signif_dig) & signif(AVAL, signif_dig) > signif(ANRHI + 20, signif_dig) ~ \"2\",  is.na(BASE) & signif(AVAL, signif_dig) > signif(ANRHI + 20, signif_dig) ~ \"2\",  !is.na(BASE) & signif(BASE, signif_dig) > signif(ANRHI, signif_dig) & signif(AVAL, signif_dig) > signif(BASE, signif_dig) ~ \"1\",  !is.na(BASE) & signif(BASE, signif_dig) <=  signif(ANRHI, signif_dig) & signif(AVAL, signif_dig) > signif(ANRHI, signif_dig) ~ \"1\",  is.na(BASE) & signif(AVAL, signif_dig) > signif(ANRHI, signif_dig) ~ \"1\",  !is.na(BASE) & signif(BASE, signif_dig) > signif(ANRHI, signif_dig) & signif(AVAL, signif_dig) <= signif(BASE, signif_dig) ~ \"0\",  !is.na(BASE) & signif(BASE, signif_dig) <=  signif(ANRHI, signif_dig) & signif(AVAL, signif_dig) <= signif(ANRHI, signif_dig) ~ \"0\",  is.na(BASE) & signif(AVAL, signif_dig) <= signif(ANRHI, signif_dig) ~ \"0\"  )","SI_UNIT_CHECK":"g/L","VAR_CHECK":"AVAL, ANRHI, BASE","DIRECTION":"H"}
{"SOC":"Investigations","TERM":"INR increased","Grade_1":">1 - 1.5 x ULN; >1 - 1.5 times above baseline if on anticoagulation","Grade_2":">1.5 - 2.5 x ULN; >1.5 - 2.5 times above baseline if on anticoagulation","Grade_3":">2.5 x ULN; >2.5 times above baseline if on anticoagulation","Grade_4":"-","Grade_5":"-","Definition":"A finding based on laboratory test results that indicate an increase in the ratio of the patient's prothrombin time to a control sample in the blood.","GRADE_CRITERIA_CODE":"case_when(  is.na(AVAL) ~ NA_character_,  !is.na(ANRHI) & signif(AVAL, signif_dig) >  signif(2.5*ANRHI, signif_dig) ~ \"3\",  !is.na(BASE) & signif( AVAL, signif_dig) > signif(2.5*BASE, signif_dig) ~ \"3\",  !is.na(ANRHI) & signif(AVAL, signif_dig) > signif(1.5*ANRHI, signif_dig) ~ \"2\",  !is.na(BASE) & signif(AVAL, signif_dig) > signif(1.5*BASE, signif_dig) ~ \"2\",  !is.na(ANRHI) & signif(AVAL, signif_dig) > signif(ANRHI, signif_dig) ~ \"1\",  !is.na(BASE) & signif(AVAL, signif_dig) > signif(BASE, signif_dig) ~ \"1\",  !is.na(ANRHI) & signif(AVAL, signif_dig) <= signif(ANRHI, signif_dig) & !is.na(BASE) & signif(AVAL, signif_dig) <= signif(BASE, signif_dig) ~ \"0\",  is.na(ANRHI) | is.na(BASE) ~ NA_character_  )","VAR_CHECK":"AVAL, ANRHI","DIRECTION":"H","COMMENT":"Take worst case and assume \"on anticoagulation\""}
{"SOC":"Investigations","TERM":"Lipase increased","Grade_1":">ULN - 1.5 x ULN","Grade_2":">1.5 - 2.0 x ULN","Grade_3":">2.0 - 5.0 x ULN","Grade_4":">5.0 x ULN","Grade_5":"-","Definition":"A finding based on laboratory test results that indicate an increase in the level of lipase in a biological specimen.","GRADE_CRITERIA_CODE":"case_when(  is.na(AVAL) | is.na(ANRHI) ~ NA_character_,  signif(AVAL, signif_dig) >  signif(5*ANRHI, signif_dig) ~ \"4\",  signif(AVAL, signif_dig) >  signif(2*ANRHI, signif_dig) ~ \"3\",  signif(AVAL, signif_dig) > signif(1.5*ANRHI, signif_dig) ~ \"2\",  signif(AVAL, signif_dig) > signif(ANRHI, signif_dig) ~ \"1\",  signif(AVAL, signif_dig) <= signif(ANRHI, signif_dig) ~ \"0\"  )","VAR_CHECK":"AVAL, ANRHI","DIRECTION":"H"}
{"SOC":"Investigations","TERM":"Lymphocyte count decreased","Grade_1":"<LLN - 800/mm3; <LLN - 0.8 x 10e9/L","Grade_2":"<800 - 500/mm3; <0.8 - 0.5 x 10e9 /L","Grade_3":"<500 - 200/mm3; <0.5 - 0.2 x 10e9 /L","Grade_4":"<200/mm3; <0.2 x 10e9 /L","Grade_5":"-","Definition":"A finding based on laboratory test results that indicate a decrease in number of lymphocytes in a blood specimen.","GRADE_CRITERIA_CODE":"case_when(  is.na(AVAL) ~ NA_character_,  signif(AVAL, signif_dig) < 0.2 ~ \"4\",  signif(AVAL, signif_dig) < 0.5 ~ \"3\",  signif(AVAL, signif_dig) < 0.8 ~ \"2\",  is.na(ANRLO) ~ NA_character_,  signif(AVAL, signif_dig) < signif(ANRLO, signif_dig) ~ \"1\",  signif(AVAL, signif_dig) >= signif(ANRLO, signif_dig) ~ \"0\"  )","SI_UNIT_CHECK":"10^9/L","VAR_CHECK":"AVAL, ANRLO","DIRECTION":"L"}
{"SOC":"Investigations","TERM":"Lymphocyte count increased","Grade_1":"-","Grade_2":">4000/mm3 - 20,000/mm3","Grade_3":">20,000/mm3","Grade_4":"-","Grade_5":"-","Definition":"A finding based on laboratory test results that indicate an abnormal increase in the number of lymphocytes in the blood, effusions or bone marrow.","GRADE_CRITERIA_CODE":"case_when(  is.na(AVAL) ~ NA_character_,  signif(AVAL, signif_dig) > 20 ~ \"3\",  signif(AVAL, signif_dig) > 4 ~ \"2\",  signif(AVAL, signif_dig) <= 4 ~ \"0\"  )","SI_UNIT_CHECK":"10^9/L","VAR_CHECK":"AVAL, ANRHI","DIRECTION":"H"}
{"SOC":"Investigations","TERM":"Neutrophil count decreased","Grade_1":"<LLN - 1500/mm3; <LLN - 1.5 x 10e9 /L","Grade_2":"<1500 - 1000/mm3; <1.5 - 1.0 x 10e9 /L","Grade_3":"<1000 - 500/mm3; <1.0 - 0.5 x 10e9 /L","Grade_4":"<500/mm3; <0.5 x 10e9 /L","Grade_5":"-","Definition":"A finding based on laboratory test results that indicate a decrease in number of neutrophils in a blood specimen.","GRADE_CRITERIA_CODE":"case_when(  is.na(AVAL) ~ NA_character_,  signif(AVAL, signif_dig) < 0.5 ~ \"4\",  signif(AVAL, signif_dig) < 1 ~ \"3\",  signif(AVAL, signif_dig) < 1.5 ~ \"2\",  is.na(ANRLO) ~ NA_character_,  signif(AVAL, signif_dig) < signif(ANRLO, signif_dig) ~ \"1\",  signif(AVAL, signif_dig) >= signif(ANRLO, signif_dig) ~ \"0\"  )","SI_UNIT_CHECK":"10^9/L","VAR_CHECK":"AVAL, ANRLO","DIRECTION":"L"}
{"SOC":"Investigations","TERM":"Platelet count decreased","Grade_1":"<LLN - 75,000/mm3; <LLN - 75.0 x 10e9 /L","Grade_2":"<75,000 - 50,000/mm3; <75.0 - 50.0 x 10e9 /L","Grade_3":"<50,000 - 25,000/mm3; <50.0 - 25.0 x 10e9 /L","Grade_4":"<25,000/mm3; <25.0 x 10e9 /L","Grade_5":"-","Definition":"A finding based on laboratory test results that indicate a decrease in number of platelets in a blood specimen.","GRADE_CRITERIA_CODE":"case_when(  is.na(AVAL) ~ NA_character_,  signif(AVAL, signif_dig) < 25 ~ \"4\",  signif(AVAL, signif_dig) < 50 ~ \"3\",  signif(AVAL, signif_dig) < 75 ~ \"2\",  is.na(ANRLO) ~ NA_character_,  signif(AVAL, signif_dig) < signif(ANRLO, signif_dig) ~ \"1\",  signif(AVAL, signif_dig) >= signif(ANRLO, signif_dig) ~ \"0\"  )","SI_UNIT_CHECK":"10^9/L","VAR_CHECK":"AVAL, ANRLO","DIRECTION":"L"}
{"SOC":"Investigations","TERM":"Serum amylase increased","Grade_1":">ULN - 1.5 x ULN","Grade_2":">1.5 - 2.0 x ULN","Grade_3":">2.0 - 5.0 x ULN","Grade_4":">5.0 x ULN","Grade_5":"-","Definition":"A finding based on laboratory test results that indicate an increase in the levels of amylase in a serum specimen.","GRADE_CRITERIA_CODE":"case_when(  is.na(AVAL) | is.na(ANRHI) ~ NA_character_,  signif(AVAL, signif_dig) >  signif(5*ANRHI, signif_dig) ~ \"4\",  signif(AVAL, signif_dig) >  signif(2*ANRHI, signif_dig) ~ \"3\",  signif(AVAL, signif_dig) > signif(1.5*ANRHI, signif_dig) ~ \"2\",  signif(AVAL, signif_dig) > signif(ANRHI, signif_dig) ~ \"1\",  signif(AVAL, signif_dig) <= signif(ANRHI, signif_dig) ~ \"0\"  )","VAR_CHECK":"AVAL, ANRHI","DIRECTION":"H"}
{"SOC":"Investigations","TERM":"White blood cell decreased","Grade_1":"<LLN - 3000/mm3; <LLN - 3.0 x 10e9 /L","Grade_2":"<3000 - 2000/mm3; <3.0 - 2.0 x 10e9 /L","Grade_3":"<2000 - 1000/mm3; <2.0 - 1.0 x 10e9 /L","Grade_4":"<1000/mm3; <1.0 x 10e9 /L","Grade_5":"-","Definition":"A finding based on laboratory test results that indicate an decrease in number of white blood cells in a blood specimen.","GRADE_CRITERIA_CODE":"case_when(  is.na(AVAL) ~ NA_character_,  signif(AVAL, signif_dig) < 1 ~ \"4\",  signif(AVAL, signif_dig) < 2 ~ \"3\",  signif(AVAL, signif_dig) < 3 ~ \"2\",  is.na(ANRLO) ~ NA_character_,  signif(AVAL, signif_dig) < signif(ANRLO, signif_dig) ~ \"1\",  signif(AVAL, signif_dig) >= signif(ANRLO, signif_dig) ~ \"0\"  )","SI_UNIT_CHECK":"10^9/L","VAR_CHECK":"AVAL, ANRLO","DIRECTION":"L"}
{"SOC":"Metabolism and nutrition disorders","TERM":"Hypercalcemia","Grade_1":"Corrected serum calcium of >ULN - 11.5 mg/dL; >ULN - 2.9 mmol/L;  Ionized calcium  >ULN - 1.5 mmol/L","Grade_2":"Corrected serum calcium of >11.5 - 12.5 mg/dL; >2.9 - 3.1 mmol/L;  Ionized calcium >1.5 - 1.6 mmol/L; symptomatic","Grade_3":"Corrected serum calcium of >12.5 - 13.5 mg/dL;>3.1 - 3.4 mmol/L;  Ionized calcium  >1.6 - 1.8 mmol/L; hospitalization indicated","Grade_4":"Corrected serum calcium of >13.5 mg/dL; >3.4 mmol/L;  Ionized calcium  >1.8 mmol/L; life-threatening consequences","Grade_5":"Death","Definition":"A disorder characterized by laboratory test results that indicate an elevation in the concentration of calcium (corrected for albumin) in blood.","GRADE_CRITERIA_CODE":"case_when(  is.na(AVAL) ~ NA_character_,  signif(AVAL, signif_dig) > 3.4 ~ \"4\",  signif(AVAL, signif_dig) > 3.1 ~ \"3\",  signif(AVAL, signif_dig) > 2.9 ~ \"2\",  is.na(ANRHI) ~ NA_character_,  signif(AVAL, signif_dig) > signif(ANRHI, signif_dig) ~ \"1\",  signif(AVAL, signif_dig) <= signif(ANRHI, signif_dig) ~ \"0\"  )","SI_UNIT_CHECK":"MMOL/L","VAR_CHECK":"AVAL, ANRHI","DIRECTION":"H","COMMENT":"Split Corrected Calcium and Ionized Calcium into 2 separate terms."}
{"SOC":"Metabolism and nutrition disorders","TERM":"Hypercalcemia (Ionized)","Grade_1":"Corrected serum calcium of >ULN - 11.5 mg/dL; >ULN - 2.9 mmol/L;  Ionized calcium  >ULN - 1.5 mmol/L","Grade_2":"Corrected serum calcium of >11.5 - 12.5 mg/dL; >2.9 - 3.1 mmol/L;  Ionized calcium >1.5 - 1.6 mmol/L; symptomatic","Grade_3":"Corrected serum calcium of >12.5 - 13.5 mg/dL;>3.1 - 3.4 mmol/L;  Ionized calcium  >1.6 - 1.8 mmol/L; hospitalization indicated","Grade_4":"Corrected serum calcium of >13.5 mg/dL; >3.4 mmol/L;  Ionized calcium  >1.8 mmol/L; life-threatening consequences","Grade_5":"Death","Definition":"A disorder characterized by laboratory test results that indicate an elevation in the concentration of calcium (corrected for albumin) in blood.","GRADE_CRITERIA_CODE":"case_when(  is.na(AVAL) ~ NA_character_,  signif(AVAL, signif_dig) > 1.8 ~ \"4\",  signif(AVAL, signif_dig) > 1.6 ~ \"3\",  signif(AVAL, signif_dig) > 1.5 ~ \"2\",  is.na(ANRHI) ~ NA_character_,  signif(AVAL, signif_dig) > signif(ANRHI, signif_dig) ~ \"1\",  signif(AVAL, signif_dig) <= signif(ANRHI, signif_dig) ~ \"0\"  )","SI_UNIT_CHECK":"MMOL/L","VAR_CHECK":"AVAL, ANRHI","DIRECTION":"H","COMMENT":"Split Corrected Calcium and Ionized Calcium into 2 separate terms."}
{"SOC":"Metabolism and nutrition disorders","TERM":"Hyperglycemia (Fasting)","Grade_1":"Fasting glucose value >ULN - 160 mg/dL; Fasting glucose value >ULN - 8.9 mmol/L","Grade_2":"Fasting glucose value >160 - 250 mg/dL; Fasting glucose value >8.9 - 13.9 mmol/L","Grade_3":">250 - 500 mg/dL; >13.9 - 27.8 mmol/L; hospitalization indicated","Grade_4":">500 mg/dL; >27.8 mmol/L; life-threatening consequences","Grade_5":"Death","Definition":"A disorder characterized by laboratory test results that indicate an elevation in the concentration of blood sugar. It is usually an indication of diabetes mellitus or glucose intolerance.","GRADE_CRITERIA_CODE":"case_when(  is.na(AVAL) ~ NA_character_,  signif(AVAL, signif_dig) > 27.8 ~ \"4\",  signif(AVAL, signif_dig) > 13.9 ~ \"3\",  signif(AVAL, signif_dig) > 8.9 ~ \"2\",  is.na(ANRHI) ~ NA_character_,  signif(AVAL, signif_dig) > signif(ANRHI, signif_dig) ~ \"1\",  signif(AVAL, signif_dig) <= signif(ANRHI, signif_dig) ~ \"0\"  )","SI_UNIT_CHECK":"MMOL/L","VAR_CHECK":"AVAL, ANRHI","DIRECTION":"H","COMMENT":"Split Fasting Glucose and Glucose into 2 separate terms."}
{"SOC":"Metabolism and nutrition disorders","TERM":"Hyperglycemia","Grade_1":"Fasting glucose value >ULN - 160 mg/dL; Fasting glucose value >ULN - 8.9 mmol/L","Grade_2":"Fasting glucose value >160 - 250 mg/dL; Fasting glucose value >8.9 - 13.9 mmol/L","Grade_3":">250 - 500 mg/dL; >13.9 - 27.8 mmol/L; hospitalization indicated","Grade_4":">500 mg/dL; >27.8 mmol/L; life-threatening consequences","Grade_5":"Death","Definition":"A disorder characterized by laboratory test results that indicate an elevation in the concentration of blood sugar. It is usually an indication of diabetes mellitus or glucose intolerance.","GRADE_CRITERIA_CODE":"case_when(  is.na(AVAL) ~ NA_character_,  signif(AVAL, signif_dig) > 27.8 ~ \"4\",  signif(AVAL, signif_dig) > 13.9 ~ \"3\",  signif(AVAL, signif_dig) <= 13.9 ~ \"0\"  )","SI_UNIT_CHECK":"MMOL/L","VAR_CHECK":"AVAL","DIRECTION":"H","COMMENT":"Split Fasting Glucose and Glucose into 2 separate terms."}
{"SOC":"Metabolism and nutrition disorders","TERM":"Hyperkalemia","Grade_1":">ULN - 5.5 mmol/L","Grade_2":">5.5 - 6.0 mmol/L","Grade_3":">6.0 - 7.0 mmol/L; hospitalization indicated","Grade_4":">7.0 mmol/L; life-threatening consequences","Grade_5":"Death","Definition":"A disorder characterized by laboratory test results that indicate an elevation in the concentration of potassium in the blood; associated with kidney failure or sometimes with the use of diuretic drugs.","GRADE_CRITERIA_CODE":"case_when(  is.na(AVAL) ~ NA_character_,  signif(AVAL, signif_dig) > 7 ~ \"4\",  signif(AVAL, signif_dig) > 6 ~ \"3\",  signif(AVAL, signif_dig) > 5.5 ~ \"2\",  is.na(ANRHI) ~ NA_character_,  signif(AVAL, signif_dig) > signif(ANRHI, signif_dig) ~ \"1\",  signif(AVAL, signif_dig) <= signif(ANRHI, signif_dig) ~ \"0\"  )","SI_UNIT_CHECK":"MMOL/L","VAR_CHECK":"AVAL, ANRHI","DIRECTION":"H"}
{"SOC":"Metabolism and nutrition disorders","TERM":"Hypermagnesemia","Grade_1":">ULN - 3.0 mg/dL; >ULN - 1.23 mmol/L","Grade_2":"-","Grade_3":">3.0 - 8.0 mg/dL; >1.23 - 3.30 mmol/L","Grade_4":">8.0 mg/dL; >3.30 mmol/L; life-threatening consequences","Grade_5":"Death","Definition":"A disorder characterized by laboratory test results that indicate an elevation in the concentration of magnesium in the  blood.","GRADE_CRITERIA_CODE":"case_when(  is.na(AVAL) ~ NA_character_,  signif(AVAL, signif_dig) > 3.3 ~ \"4\",  signif(AVAL, signif_dig) > 1.23 ~ \"3\",  is.na(ANRHI) ~ NA_character_,  signif(AVAL, signif_dig) > signif(ANRHI, signif_dig) ~ \"1\",  signif(AVAL, signif_dig) <= signif(ANRHI, signif_dig) ~ \"0\"  )","SI_UNIT_CHECK":"MMOL/L","VAR_CHECK":"AVAL, ANRHI","DIRECTION":"H"}
{"SOC":"Metabolism and nutrition disorders","TERM":"Hypernatremia","Grade_1":">ULN - 150 mmol/L","Grade_2":">150 - 155 mmol/L","Grade_3":">155 - 160 mmol/L; hospitalization indicated","Grade_4":">160 mmol/L; life-threatening consequences","Grade_5":"Death","Definition":"A disorder characterized by laboratory test results that indicate an elevation in the concentration of sodium in the  blood.","GRADE_CRITERIA_CODE":"case_when(  is.na(AVAL) ~ NA_character_,  signif(AVAL, signif_dig) > 160 ~ \"4\",  signif(AVAL, signif_dig) > 155 ~ \"3\",  signif(AVAL, signif_dig) > 150 ~ \"2\",  is.na(ANRHI) ~ NA_character_,  signif(AVAL, signif_dig) > signif(ANRHI, signif_dig) ~ \"1\",  signif(AVAL, signif_dig) <= signif(ANRHI, signif_dig) ~ \"0\"  )","SI_UNIT_CHECK":"MMOL/L","VAR_CHECK":"AVAL, ANRHI","DIRECTION":"H"}
{"SOC":"Metabolism and nutrition disorders","TERM":"Hypertriglyceridemia","Grade_1":"150 mg/dL - 300 mg/dL; 1.71 mmol/L - 3.42 mmol/L","Grade_2":">300 mg/dL - 500 mg/dL;  >3.42 mmol/L - 5.7 mmol/L","Grade_3":">500 mg/dL - 1000 mg/dL;  >5.7 mmol/L - 11.4 mmol/L","Grade_4":">1000 mg/dL; >11.4 mmol/L;  life-threatening consequences","Grade_5":"Death","Definition":"A disorder characterized by laboratory test results that indicate an elevation in the concentration of triglyceride concentration in the blood.","GRADE_CRITERIA_CODE":"case_when(  is.na(AVAL) ~ NA_character_,  signif(AVAL, signif_dig) > 11.4 ~ \"4\",  signif(AVAL, signif_dig) > 5.7 ~ \"3\",  signif(AVAL, signif_dig) > 3.42 ~ \"2\",  signif(AVAL, signif_dig) > 1.71 ~ \"1\",  signif(AVAL, signif_dig) <= 1.71 ~ \"0\"  )","SI_UNIT_CHECK":"MMOL/L","VAR_CHECK":"AVAL","DIRECTION":"H"}
{"SOC":"Metabolism and nutrition disorders","TERM":"Hyperuricemia","Grade_1":">ULN - 10 mg/dL (0.59 mmol/L) without physiologic consequences","Grade_2":"-","Grade_3":">ULN - 10 mg/dL (0.59 mmol/L) with physiologic consequences","Grade_4":">10 mg/dL; >0.59 mmol/L; life-threatening consequences","Grade_5":"Death","Definition":"A disorder characterized by laboratory test results that indicate an elevation in the concentration of uric acid.","GRADE_CRITERIA_CODE":"case_when(  is.na(AVAL) ~ NA_character_,  signif(AVAL, signif_dig) > 590 ~ \"4\",  is.na(ANRHI) ~ NA_character_,  signif(AVAL, signif_dig) > signif(ANRHI, signif_dig) ~ \"3\",  signif(AVAL, signif_dig) <= signif(ANRHI, signif_dig) ~ \"0\"  )","SI_UNIT_CHECK":"UMOL/L","VAR_CHECK":"AVAL, ANRHI","DIRECTION":"H","COMMENT":"Take worst case and assume \"with physiologic consequences\""}
{"SOC":"Metabolism and nutrition disorders","TERM":"Hypoalbuminemia","Grade_1":"<LLN - 3 g/dL; <LLN - 30 g/L","Grade_2":"<3 - 2 g/dL; <30 - 20 g/L","Grade_3":"<2 g/dL; <20 g/L","Grade_4":"Life-threatening consequences; urgent intervention indicated","Grade_5":"Death","Definition":"A disorder characterized by laboratory test results that indicate a low concentration of albumin in the blood.","GRADE_CRITERIA_CODE":"case_when(  is.na(AVAL) ~ NA_character_,  signif(AVAL, signif_dig) < 20 ~ \"3\",  signif(AVAL, signif_dig) < 30 ~ \"2\",  is.na(ANRLO) ~ NA_character_,  signif(AVAL, signif_dig) < signif(ANRLO, signif_dig) ~ \"1\",  signif(AVAL, signif_dig) >= signif(ANRLO, signif_dig) ~ \"0\"  )","SI_UNIT_CHECK":"g/L","VAR_CHECK":"AVAL, ANRLO","DIRECTION":"L"}
{"SOC":"Metabolism and nutrition disorders","TERM":"Hypocalcemia","Grade_1":"Corrected serum calcium of <LLN - 8.0 mg/dL; <LLN - 2.0 mmol/L; Ionized calcium  <LLN - 1.0 mmol/L","Grade_2":"Corrected serum calcium of <8.0 - 7.0 mg/dL; <2.0 - 1.75 mmol/L; Ionized calcium  <1.0 - 0.9 mmol/L; symptomatic","Grade_3":"Corrected serum calcium of <7.0 - 6.0 mg/dL; <1.75 - 1.5 mmol/L;  Ionized calcium  <0.9 - 0.8 mmol/L; hospitalization indicated","Grade_4":"Corrected serum calcium of  <6.0 mg/dL; <1.5 mmol/L;  Ionized calcium  <0.8 mmol/L; life-threatening consequences","Grade_5":"Death","Definition":"A disorder characterized by laboratory test results that indicate a low concentration of calcium (corrected for albumin) in the  blood.","GRADE_CRITERIA_CODE":"case_when(  is.na(AVAL) ~ NA_character_,  signif(AVAL, signif_dig) < 1.5 ~ \"4\",  signif(AVAL, signif_dig) < 1.75 ~ \"3\",  signif(AVAL, signif_dig) < 2 ~ \"2\",  is.na(ANRLO) ~ NA_character_,  signif(AVAL, signif_dig) < signif(ANRLO, signif_dig) ~ \"1\",  signif(AVAL, signif_dig) >= signif(ANRLO, signif_dig) ~ \"0\"  )","SI_UNIT_CHECK":"MMOL/L","VAR_CHECK":"AVAL, ANRLO","DIRECTION":"L","COMMENT":"Split Corrected Calcium and Ionized Calcium into 2 separate terms."}
{"SOC":"Metabolism and nutrition disorders","TERM":"Hypocalcemia (Ionized)","Grade_1":"Corrected serum calcium of <LLN - 8.0 mg/dL; <LLN - 2.0 mmol/L; Ionized calcium  <LLN - 1.0 mmol/L","Grade_2":"Corrected serum calcium of <8.0 - 7.0 mg/dL; <2.0 - 1.75 mmol/L; Ionized calcium  <1.0 - 0.9 mmol/L; symptomatic","Grade_3":"Corrected serum calcium of <7.0 - 6.0 mg/dL; <1.75 - 1.5 mmol/L;  Ionized calcium  <0.9 - 0.8 mmol/L; hospitalization indicated","Grade_4":"Corrected serum calcium of  <6.0 mg/dL; <1.5 mmol/L;  Ionized calcium  <0.8 mmol/L; life-threatening consequences","Grade_5":"Death","Definition":"A disorder characterized by laboratory test results that indicate a low concentration of calcium (corrected for albumin) in the  blood.","GRADE_CRITERIA_CODE":"case_when(  is.na(AVAL) ~ NA_character_,  signif(AVAL, signif_dig) < 0.8 ~ \"4\",  signif(AVAL, signif_dig) < 0.9 ~ \"3\",  signif(AVAL, signif_dig) < 1 ~ \"2\",  is.na(ANRLO) ~ NA_character_,  signif(AVAL, signif_dig) < signif(ANRLO, signif_dig) ~ \"1\",  signif(AVAL, signif_dig) >= signif(ANRLO, signif_dig) ~ \"0\"  )","SI_UNIT_CHECK":"MMOL/L","VAR_CHECK":"AVAL, ANRLO","DIRECTION":"L","COMMENT":"Split Corrected Calcium and Ionized Calcium into 2 separate terms."}
{"SOC":"Metabolism and nutrition disorders","TERM":"Hypoglycemia","Grade_1":"<LLN - 55 mg/dL; <LLN - 3.0 mmol/L","Grade_2":"<55 - 40 mg/dL; <3.0 - 2.2 mmol/L","Grade_3":"<40 - 30 mg/dL; <2.2 - 1.7 mmol/L","Grade_4":"<30 mg/dL; <1.7 mmol/L; life-threatening consequences; seizures","Grade_5":"Death","Definition":"A disorder characterized by laboratory test results that indicate a low concentration of glucose in the blood.","GRADE_CRITERIA_CODE":"case_when(  is.na(AVAL) ~ NA_character_,  signif(AVAL, signif_dig) < 1.7 ~ \"4\",  signif(AVAL, signif_dig) < 2.2 ~ \"3\",  signif(AVAL, signif_dig) < 3 ~ \"2\",  is.na(ANRLO) ~ NA_character_,  signif(AVAL, signif_dig) < signif(ANRLO, signif_dig) ~ \"1\",  signif(AVAL, signif_dig) >= signif(ANRLO, signif_dig) ~ \"0\"  )","SI_UNIT_CHECK":"MMOL/L","VAR_CHECK":"AVAL, ANRLO","DIRECTION":"L"}
{"SOC":"Metabolism and nutrition disorders","TERM":"Hypokalemia","Grade_1":"<LLN - 3.0 mmol/L","Grade_2":"<LLN - 3.0 mmol/L; symptomatic; intervention indicated","Grade_3":"<3.0 - 2.5 mmol/L; hospitalization indicated","Grade_4":"<2.5 mmol/L; life-threatening consequences","Grade_5":"Death","Definition":"A disorder characterized by laboratory test results that indicate a low concentration of potassium in the  blood.","GRADE_CRITERIA_CODE":"case_when(  is.na(AVAL) ~ NA_character_,  signif(AVAL, signif_dig) < 2.5 ~ \"4\",  signif(AVAL, signif_dig) < 3 ~ \"3\",  is.na(ANRLO) ~ NA_character_,  signif(AVAL, signif_dig) < signif(ANRLO, signif_dig) ~ \"2\",  signif(AVAL, signif_dig) >= signif(ANRLO, signif_dig) ~ \"0\"  )","SI_UNIT_CHECK":"MMOL/L","VAR_CHECK":"AVAL, ANRLO","DIRECTION":"L","COMMENT":"Take worst case and assume \"symptomatic OR intervention indicated\""}
{"SOC":"Metabolism and nutrition disorders","TERM":"Hypomagnesemia","Grade_1":"<LLN - 1.2 mg/dL; <LLN - 0.5 mmol/L","Grade_2":"<1.2 - 0.9 mg/dL; <0.5 - 0.4 mmol/L","Grade_3":"<0.9 - 0.7 mg/dL; <0.4 - 0.3 mmol/L","Grade_4":"<0.7 mg/dL; <0.3 mmol/L; life-threatening consequences","Grade_5":"Death","Definition":"A disorder characterized by laboratory test results that indicate a low concentration of magnesium in the  blood.","GRADE_CRITERIA_CODE":"case_when(  is.na(AVAL) ~ NA_character_,  signif(AVAL, signif_dig) < 0.3 ~ \"4\",  signif(AVAL, signif_dig) < 0.4 ~ \"3\",  signif(AVAL, signif_dig) < 0.5 ~ \"2\",  is.na(ANRLO) ~ NA_character_,  signif(AVAL, signif_dig) < signif(ANRLO, signif_dig) ~ \"1\",  signif(AVAL, signif_dig) >= signif(ANRLO, signif_dig) ~ \"0\"  )","SI_UNIT_CHECK":"MMOL/L","VAR_CHECK":"AVAL, ANRLO","DIRECTION":"L"}
{"SOC":"Metabolism and nutrition disorders","TERM":"Hyponatremia","Grade_1":"<LLN - 130 mmol/L","Grade_2":"-","Grade_3":"<130 - 120 mmol/L","Grade_4":"<120 mmol/L; life-threatening consequences","Grade_5":"Death","Definition":"A disorder characterized by laboratory test results that indicate a low concentration of sodium in the blood.","GRADE_CRITERIA_CODE":"case_when(  is.na(AVAL) ~ NA_character_,  signif(AVAL, signif_dig) < 120 ~ \"4\",  signif(AVAL, signif_dig) < 130 ~ \"3\",  is.na(ANRLO) ~ NA_character_,  signif(AVAL, signif_dig) < signif(ANRLO, signif_dig) ~ \"1\",  signif(AVAL, signif_dig) >= signif(ANRLO, signif_dig) ~ \"0\"  )","SI_UNIT_CHECK":"MMOL/L","VAR_CHECK":"AVAL, ANRLO","DIRECTION":"L"}
{"SOC":"Metabolism and nutrition disorders","TERM":"Hypophosphatemia","Grade_1":"<LLN - 2.5 mg/dL; <LLN - 0.8 mmol/L","Grade_2":"<2.5 - 2.0 mg/dL; <0.8 - 0.6 mmol/L","Grade_3":"<2.0 - 1.0 mg/dL; <0.6 - 0.3 mmol/L","Grade_4":"<1.0 mg/dL; <0.3 mmol/L; life-threatening consequences","Grade_5":"Death","Definition":"A disorder characterized by laboratory test results that indicate a low concentration of phosphates in the  blood.","GRADE_CRITERIA_CODE":"case_when(  is.na(AVAL) ~ NA_character_,  signif(AVAL, signif_dig) < 0.3 ~ \"4\",  signif(AVAL, signif_dig) < 0.6 ~ \"3\",  signif(AVAL, signif_dig) < 0.8 ~ \"2\",  is.na(ANRLO) ~ NA_character_,  signif(AVAL, signif_dig) < signif(ANRLO, signif_dig) ~ \"1\",  signif(AVAL, signif_dig) >= signif(ANRLO, signif_dig) ~ \"0\"  )","SI_UNIT_CHECK":"MMOL/L","VAR_CHECK":"AVAL, ANRLO","DIRECTION":"L"}